List of Publications:

  1. In-Silico and In-Vitro Analysis of Human SOS1 Protein Causing Noonan Syndrome – A Novel Approach to Explore the Molecular Pathways. Sigamani V, Rajasingh S, Gurusamy N, Panda A, Rajasingh J.Curr Genomics. 2021 Dec 31;22(7):526-540. doi: 10.2174/1389202922666211130144221.PMID: 35386434 Free PMC article.
  2. Mesenchymal Stem Cell Induced Foxp3(+) Tregs Suppress Effector T Cells and Protect against Retinal Ischemic Injury. Agrawal M, Rasiah PK, Bajwa A, Rajasingh J, Gangaraju R.Cells. 2021 Nov 4;10(11):3006. doi: 10.3390/cells10113006.PMID: 34831229 Free PMC article.
  3. Modern approaches on stem cells and scaffolding technology for osteogenic differentiation and regeneration. Kirankumar S, Gurusamy N, Rajasingh S, Sigamani V, Vasanthan J, Perales SG, Rajasingh J.Exp Biol Med (Maywood). 2022 Mar;247(5):433-445. doi: 10.1177/15353702211052927. Epub 2021 Oct 14.PMID: 34648374 Review.
  4. Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases. Jayaraman S, Gnanasampanthapandian D, Rajasingh J, Palaniyandi K.Front Cardiovasc Med. 2021 Aug 10;8:723236. doi: 10.3389/fcvm.2021.723236. eCollection 2021.PMID: 34447796 Free PMC article. Review.
  5. Comparative analysis of human induced pluripotent stem cell-derived mesenchymal stem cells and umbilical cord mesenchymal stem cells. Rajasingh S, Sigamani V, Selvam V, Gurusamy N, Kirankumar S, Vasanthan J, Rajasingh J.J Cell Mol Med. 2021 Sep;25(18):8904-8919. doi: 10.1111/jcmm.16851. Epub 2021 Aug 13.PMID: 34390186 Free PMC article.
  6. Efficient and Safe Method of Generating Induced Pluripotent Stem Cells from Human Skin Fibroblasts and Subsequent Differentiation into Functional Cardiomyocytes. Rajasingh S, Sigamani V, Gurusamy N, Rajasingh J.Methods Mol Biol. 2022;2454:197-212. doi: 10.1007/7651_2021_353.PMID: 33774811
  7. Noonan syndrome patient-specific induced cardiomyocyte model carrying SOS1 gene variant c.1654A>G. Gurusamy N, Rajasingh S, Sigamani V, Rajasingh R, Isai DG, Czirok A, Bittel D, Rajasingh J.Exp Cell Res. 2021 Mar 1;400(1):112508. doi: 10.1016/j.yexcr.2021.112508. Epub 2021 Feb 4.PMID: 33549576 Free PMC article.
  8. Role of Human Mesenchymal Stem Cells in Regenerative Therapy. Vasanthan J, Gurusamy N, Rajasingh S, Sigamani V, Kirankumar S, Thomas EL, Rajasingh J.Cells. 2020 Dec 31;10(1):54. doi: 10.3390/cells10010054.PMID: 33396426 Free PMC article. Review.
  9.  Non-viral reprogramming and induced pluripotent stem cells for cardiovascular therapy. Panda A, Gurusamy N, Rajasingh S, Carter HK, Thomas EL, Rajasingh J.Differentiation. 2020 Mar-Apr;112:58-66. doi: 10.1016/j.diff.2019.12.001. Epub 2020 Jan 10.PMID: 31954271 Free PMC article. Review.
  10. Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung. Menden H, Xia S, Mabry SM, Noel-MacDonnell J, Rajasingh J, Ye SQ, Sampath V.Am J Physiol Lung Cell Mol Physiol. 2019 Sep 1;317(3):L332-L346. doi: 10.1152/ajplung.00247.2018. Epub 2019 Jul 3.PMID: 31268348 Free PMC article.
  11. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V.Pediatr Res. 2020 Jan;87(2):265-276. doi: 10.1038/s41390-019-0425-5. Epub 2019 May 14.PMID: 31086355 Free PMC article. Review.
  12. Modern human lifestyle prejudices epigenetic changes to cuddle diseases. Gurusamy N, Rajasingh J.Ann Transl Med. 2019 Mar;7(5):82. doi: 10.21037/atm.2018.12.70.PMID: 31019932 Free PMC article. No abstract available.
  13. Adult Stem Cells for Regenerative Therapy. Gurusamy N, Alsayari A, Rajasingh S, Rajasingh J.Prog Mol Biol Transl Sci. 2018;160:1-22. doi: 10.1016/bs.pmbts.2018.07.009. Epub 2018 Sep 6.PMID: 30470288 Review.
  14. DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling. Samanta S, Zhou Z, Rajasingh S, Panda A, Sampath V, Rajasingh J.Int J Biochem Cell Biol. 2018 Sep;102:117-127. doi: 10.1016/j.biocel.2018.07.002. Epub 2018 Jul 24.PMID: 30010012 Free PMC article.
  15. Manipulation-free cultures of human iPSC-derived cardiomyocytes offer a novel screening method for cardiotoxicity. Rajasingh S, Isai DG, Samanta S, Zhou ZG, Dawn B, Kinsey WH, Czirok A, Rajasingh J.Acta Pharmacol Sin. 2018 Oct;39(10):1590-1603. doi: 10.1038/aps.2017.183. Epub 2018 Apr 5.PMID: 29620051 Free PMC article.
  16. Left Atrial Appendage Closure and Systemic Homeostasis: The LAA HOMEOSTASIS Study. Lakkireddy D, Turagam M, Afzal MR, Rajasingh J, Atkins D, Dawn B, Di Biase L, Bartus K, Kar S, Natale A, Holmes DJ Jr.J Am Coll Cardiol. 2018 Jan 16;71(2):135-144. doi: 10.1016/j.jacc.2017.10.092.PMID: 29325636 Free article.
  17. Use of Oral Steroid and its Effects on Atrial Fibrillation Recurrence and Inflammatory Cytokines Post Ablation – The Steroid AF Study. Iskandar S, Reddy M, Afzal MR, Rajasingh J, Atoui M, Lavu M, Atkins D, Bommana S, Umbarger L, Jaeger M, Pimentel R, Dendi R, Emert M, Turagam M, Di Biase L, Natale A, Lakkireddy D.J Atr Fibrillation. 2017 Feb 28;9(5):1604. doi: 10.4022/jafib.1604. eCollection 2017 Feb-Mar.PMID: 29250282 Free PMC article.
  18. Exosomes: new molecular targets of diseases. Samanta S, Rajasingh S, Drosos N, Zhou Z, Dawn B, Rajasingh J.Acta Pharmacol Sin. 2018 Apr;39(4):501-513. doi: 10.1038/aps.2017.162. Epub 2017 Dec 7.PMID: 29219950 Free PMC article. Review.
  19. Extracellular Vesicles in Cardiovascular Theranostics. Bei Y, Das S, Rodosthenous RS, Holvoet P, Vanhaverbeke M, Monteiro MC, Monteiro VVS, Radosinska J, Bartekova M, Jansen F, Li Q, Rajasingh J, Xiao J.Theranostics. 2017 Sep 26;7(17):4168-4182. doi: 10.7150/thno.21274. eCollection 2017.PMID: 29158817 Free PMC article. Review.
  20. Exosomes: Outlook for Future Cell-Free Cardiovascular Disease Therapy. Barani B, Rajasingh S, Rajasingh J.Adv Exp Med Biol. 2017;998:285-307. doi: 10.1007/978-981-10-4397-0_19.PMID: 28936747 Review.
  21. Optical-flow based non-invasive analysis of cardiomyocyte contractility. Czirok A, Isai DG, Kosa E, Rajasingh S, Kinsey W, Neufeld Z, Rajasingh J.Sci Rep. 2017 Sep 4;7(1):10404. doi: 10.1038/s41598-017-10094-7.PMID: 28871207 Free PMC article.
  22. Biology and clinical relevance of noncoding sno/scaRNAs. Cao T, Rajasingh S, Samanta S, Dawn B, Bittel DC, Rajasingh J.Trends Cardiovasc Med. 2018 Feb;28(2):81-90. doi: 10.1016/j.tcm.2017.08.002. Epub 2017 Aug 12.PMID: 28869095 Free PMC article. Review.
  23. Nanodiamond-based injectable hydrogel for sustained growth factor release: Preparation, characterization and in vitro analysis. Pacelli S, Acosta F, Chakravarti AR, Samanta SG, Whitlow J, Modaresi S, Ahmed RPH, Rajasingh J, Paul A.Acta Biomater. 2017 Aug;58:479-491. doi: 10.1016/j.actbio.2017.05.026. Epub 2017 May 19.PMID: 28532899 Free PMC article.
  24. Epigenetic dysfunctional diseases and therapy for infection and inflammation. Samanta S, Rajasingh S, Cao T, Dawn B, Rajasingh J.Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):518-528. doi: 10.1016/j.bbadis.2016.11.030. Epub 2016 Dec 3.PMID: 27919711 Free PMC article. Review.
  25. Circulating fibrocytes serve as a marker for clinical diagnosis. Cao T, Rajasingh S, Rajasingh J.Ann Transl Med. 2016 Oct;4(Suppl 1):S38. doi: 10.21037/atm.2016.10.26.PMID: 27868006 Free PMC article. No abstract available.
  26. Macrophage polarization in response to epigenetic modifiers during infection and inflammation. Patel U, Rajasingh S, Samanta S, Cao T, Dawn B, Rajasingh J.Drug Discov Today. 2017 Jan;22(1):186-193. doi: 10.1016/j.drudis.2016.08.006. Epub 2016 Aug 21.PMID: 27554801 Free PMC article. Review.
  27. MicroRNA: A new therapeutic strategy for cardiovascular diseases. Samanta S, Balasubramanian S, Rajasingh S, Patel U, Dhanasekaran A, Dawn B, Rajasingh J.Trends Cardiovasc Med. 2016 Jul;26(5):407-19. doi: 10.1016/j.tcm.2016.02.004. Epub 2016 Mar 3.PMID: 27013138 Free PMC article. Review.
  28. Generation of Functional Cardiomyocytes from Efficiently Generated Human iPSCs and a Novel Method of Measuring Contractility. Rajasingh S, Thangavel J, Czirok A, Samanta S, Roby KF, Dawn B, Rajasingh J.PLoS One. 2015 Aug 3;10(8):e0134093. doi: 10.1371/journal.pone.0134093. eCollection 2015.PMID: 26237415 Free PMC article.
  29. Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. Thangavel J, Samanta S, Rajasingh S, Barani B, Xuan YT, Dawn B, Rajasingh J.J Cell Sci. 2015 Aug 15;128(16):3094-105. doi: 10.1242/jcs.170258. Epub 2015 Jun 26.PMID: 26116574 Free PMC article.
  30. The many facets of RNA-binding protein HuR. Rajasingh J.Trends Cardiovasc Med. 2015 Nov;25(8):684-6. doi: 10.1016/j.tcm.2015.03.013. Epub 2015 Mar 31.PMID: 25920625 Free PMC article. No abstract available.
  31. Effect of atrial fibrillation ablation on gastric motility: the atrial fibrillation gut study. Lakkireddy D, Reddy YM, Atkins D, Rajasingh J, Kanmanthareddy A, Olyaee M, Dusing R, Pimentel R, Bommana S, Dawn B.Circ Arrhythm Electrophysiol. 2015 Jun;8(3):531-6. doi: 10.1161/CIRCEP.114.002508. Epub 2015 Mar 14.PMID: 25772541
  32. Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. Thangavel J, Malik AB, Elias HK, Rajasingh S, Simpson AD, Sundivakkam PK, Vogel SM, Xuan YT, Dawn B, Rajasingh J.Am J Pathol. 2014 Aug;184(8):2237-49. doi: 10.1016/j.ajpath.2014.05.008. Epub 2014 Jun 12.PMID: 24929240 Free PMC article.
  33. Reprogramming of somatic cells. Rajasingh J.Prog Mol Biol Transl Sci. 2012;111:51-82. doi: 10.1016/B978-0-12-398459-3.00003-4.PMID: 22917226 Review.
  34. Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. Rajasingh J, Thangavel J, Siddiqui MR, Gomes I, Gao XP, Kishore R, Malik AB.PLoS One. 2011;6(7):e22550. doi: 10.1371/journal.pone.0022550. Epub 2011 Jul 22.PMID: 21799893 Free PMC article.
  35. Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. Siddiqui MR, Komarova YA, Vogel SM, Gao X, Bonini MG, Rajasingh J, Zhao YY, Brovkovych V, Malik AB.J Cell Biol. 2011 May 30;193(5):841-50. doi: 10.1083/jcb.201012129.PMID: 21624953 Free PMC article.
  36. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, Kishore R.Circ Res. 2009 Jan 30;104(2):e9-18. doi: 10.1161/CIRCRESAHA.108.188243. Epub 2008 Dec 18.PMID: 19096025 Free PMC article.
  37. Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair. Rajasingh J, Lambers E, Hamada H, Bord E, Thorne T, Goukassian I, Krishnamurthy P, Rosen KM, Ahluwalia D, Zhu Y, Qin G, Losordo DW, Kishore R.Circ Res. 2008 Jun 6;102(11):e107-17. doi: 10.1161/CIRCRESAHA.108.176115. Epub 2008 May 15.PMID: 18483406 Free PMC article.
  38. STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Rajasingh J, Bord E, Hamada H, Lambers E, Qin G, Losordo DW, Kishore R.Circ Res. 2007 Oct 26;101(9):910-8. doi: 10.1161/CIRCRESAHA.107.156786. Epub 2007 Sep 6.PMID: 17823373
  39. Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice. Rajasingh J, Bord E, Qin G, Ii M, Silver M, Hamada H, Ahluwalia D, Goukassian D, Zhu Y, Losordo DW, Kishore R.Endocrinology. 2007 Aug;148(8):3618-24. doi: 10.1210/en.2006-1357. Epub 2007 May 3.PMID: 17478555
  40. IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. Rajasingh J, Bord E, Luedemann C, Asai J, Hamada H, Thorne T, Qin G, Goukassian D, Zhu Y, Losordo DW, Kishore R.FASEB J. 2006 Oct;20(12):2112-4. doi: 10.1096/fj.06-6084fje. Epub 2006 Aug 25.PMID: 16935932
  41. PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. Raikwar HP, Muthian G, Rajasingh J, Johnson CN, Bright JJ.J Neuroimmunol. 2006 Sep;178(1-2):76-86. doi: 10.1016/j.jneuroim.2006.05.013. Epub 2006 Jul 17.PMID: 16844232
  42. 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. Rajasingh J, Bright JJ.Exp Cell Res. 2006 Aug 1;312(13):2538-46. doi: 10.1016/j.yexcr.2006.04.010. Epub 2006 May 5.PMID: 16737695
  43. 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis. Muthian G, Raikwar HP, Rajasingh J, Bright JJ.J Neurosci Res. 2006 May 15;83(7):1299-309. doi: 10.1002/jnr.20826.PMID: 16547967
  44. COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis. Muthian G, Raikwar HP, Johnson C, Rajasingh J, Kalgutkar A, Marnett LJ, Bright JJ.J Clin Immunol. 2006 Jan;26(1):73-85. doi: 10.1007/s10875-006-8787-y.PMID: 16418805
  45. Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Rajasingh J, Raikwar HP, Muthian G, Johnson C, Bright JJ.Biochem Biophys Res Commun. 2006 Feb 10;340(2):359-68. doi: 10.1016/j.bbrc.2005.12.014. Epub 2005 Dec 13.PMID: 16364242
  46. PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis. Raikwar HP, Muthian G, Rajasingh J, Johnson C, Bright JJ.J Neuroimmunol. 2005 Oct;167(1-2):99-107. doi: 10.1016/j.jneuroim.2005.06.026.PMID: 16091293
  47. Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales’ disease patients. Saxena S, Rajasingh J, Biswas S, Kumar D, Shinohara T, Singh VK.Pathobiology. 1999;67(1):39-44. doi: 10.1159/000028049.PMID: 9873227
  48. Immune response of infants to fractional doses of intradermally administered inactivated poliovirus vaccine. Nirmal S, Cherian T, Samuel BU, Rajasingh J, Raghupathy P, John TJ.Vaccine. 1998 May-Jun;16(9-10):928-31. doi: 10.1016/s0264-410x(97)00293-4.PMID: 9682339 Clinical Trial.
  49. Cellular immune response to retinal S-antigen & interphotoreceptor retinoid binding protein fragments in idiopathic human uveitis. Rajasingh J, Singh VK, Singh V, Sharma K, Agarwal SS.Indian J Med Res. 1996 Apr;103:222-6.PMID: 8935743 Clinical Trial.
  50. Cellular immune responses of patients with juvenile chronic arthritis to retinal antigens and their synthetic peptides. Gupta D, Singh VK, Rajasingh J, Shinohara T, Misra R, Agarwal SS.Immunol Res. 1996;15(1):74-83. doi: 10.1007/BF02918285.PMID: 8739566
  51. Experimental poliomyelitis in bonnet monkey. Clinical features, virology and pathology. Samuel BU, Ponnuraj E, Rajasingh J, John TJ.Dev Biol Stand. 1993;78:71-8.PMID: 8388833
  52. Ulnar nerve inoculation of poliovirus in bonnet monkey: a new primate model to investigate neurovirulence. John TJ, Nambiar A, Samuel BU, Rajasingh J.Vaccine. 1992;10(8):529-32. doi: 10.1016/0264-410x(92)90352-k.PMID: 1320307
  53. Immune response of infants to inactivated poliovirus vaccine injected intradermally. Samuel BU, Cherian T, Rajasingh J, Raghupathy P, John TJ.Vaccine. 1992;10(2):135. doi: 10.1016/0264-410x(92)90039-m.PMID: 1311491 No abstract available.